Overview: The Center for Genomic Medicine (CGM) and the Department of Neurology of Massachusetts General Hospital (MGH) invites applications for full-time CGM faculty with an Assistant or Associate Professor of Neurology appointment at Harvard Medical School (HMS), commensurate with accomplishments and experiences.

The CGM is among the most vibrant hubs of genomic medicine in the world. In 2005, MGH recognized that genomics was poised to influence most areas of biomedical research and clinical medicine and founded an interdisciplinary Thematic Center to co-localize genetics research and nucleate these activities into a single community. Today, the CGM is a genomic medicine ecosystem that lies at the interface of fundamental research, technology development, and precision medicine. Our faculty bridge the largest hospital-based research program in the US at MGH with a world-renowned genomics institute in the Broad Institute of MIT and Harvard. Our programs are led by 50 HMS faculty and over 400 genome scientists. The CGM Director is Dr. Michael Talkowski, and our community also includes five Units: the Molecular Neurogenetics Unit (MNU) led by Dr. James Gusella, the Analytical and Translational Genetics Unit (ATGU) led by Dr. Mark Daly, the Psychiatric and Neurodevelopmental Genetics Unit (PNGU) led by Dr. Jordan Smoller, the Genomic Medicine Unit (GMU) led by Dr. Heidi Rehm, and the Precision Therapeutics Unit (PTU) led by Drs. Stephen Haggarty and Florian Eichler. CGM faculty are engaged in all facets of the ‘genomic medicine cycle’, which we envisage as beginning with an individual genome and advancing to surveys of diverse global populations, genetic architecture studies of rare and common diseases, variant-to-function (V2F) studies and deep interrogation of disease mechanisms, and translation to diagnoses and precision therapeutics. The CGM is also a major docking point for leadership at the Broad Institute, including eleven Institute Members and the co-directors of the Program in Medical and Population Genetics and the Stanley Center for Psychiatric Research.

Faculty Search in Genomic Medicine and Neurology: The strategic mission of the CGM is to use genomic information to predict, prevent, and treat human disease throughout the lifespan. The largest faculty constituency in the CGM is the MGH Department of Neurology, led by the Chair of Neurology and Director of the Sean M. Healey & AMG Center for ALS, Dr. Merit Cudkowicz. MGH Neurology operates the largest hospital-based neuroscience research program in the US and includes over 200 research faculty and staff with research centers, initiatives, and foci in rare neurological diseases, neurodegenerative diseases, brain health, and neurotechnology, to name just a few. Collectively the CGM and Department of Neurology were engaged in a portfolio of >$300M in research funding in 2023.

Here, the CGM and Department of Neurology are partnering in an open search in Neurogenetics. The areas of emphases include expertise in genomics and its applications to neuroscience and neurological disorders, with particular interest in the genetic architecture of neurodegenerative and neurodevelopmental disorders, systems-level V2F and mechanistic studies, sophisticated and scalable functional modeling of neuronal cell types and neurodegenerative disease, precision therapeutic development, and scalable variant interpretation. The successful candidate will have experience in bringing novel approaches and/or leveraging innovative tools and advanced genetic methods to predict, prevent, diagnose, and treat neurologic disease.

The CGM is a uniquely collaborative and inclusive environment, so applicants must integrate across the genomics community at MGH, HMS, Harvard, MIT, and the Broad Institute. The selected candidate will be appointed in Neurology and provided independent space in the CGM and, if appropriate, a relevant CGM Unit (MNU, ATGU, PNGU, GMU, PTU) with opportunity for affiliation at the Broad Institute. Competitive salary, benefits, administration, and start-up package will be provided. Teaching responsibilities will be commensurate with those required for academic advancement in the HMS tenure track system. We strongly encourage all applicants, particularly those from communities that are under-represented in medicine to apply at the following link no later than October 15, 2024 (full instructions also at this link):

https://redcap.partners.org/redcap/surveys/?s=PHLLRHJMFW4897JH

Please submit: (i) a CV including full publication record, (ii) a statement of research including prior research accomplishments and future research plans (3-page limit, exclusive of references), (iii) a separate summary of three, selected, impactful publications most relevant to this search with full citation (less than 300 words each), and (iv) contact information for three referees who will submit letters of recommendation on your behalf directly to CGM-officemanager@mgb.org. Questions can be directed to CGM Associate Director and search committee Chair Dr. Alex Soukas (asoukas@mgh.harvard.edu) or MGH Neurology Vice Chair for Research Dr. Craig Blackstone (cblackstone@mgh.harvard.edu).

We are equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, national origin, disability status, protected veteran status, pregnancy and pregnancy-related conditions, or any other characteristic protected by law.