Develop strategies to cellularize 3D printed scaffolds to generate functional tissue engineered lungs. Create, optimize, and implement analytical metrics that provide insight into the stability and function of printed scaffolding material. Provide expertise on lung tissue engineering methodologies and techniques required to generate a cellularized 3D printed lung scaffold. Support the development of methods and protocols to produce cellularized 3D printed lung constructs which are suitable for pre-clinical and in-vitro functional evaluation.
Key Job Responsibilities
Actively support or lead efforts to create, develop, and evaluate cellularized 3D printed bioscaffolds for lung tissue engineering
Establish and maintain a deep understanding of current and emerging technology in lung cell biology, lung physiology, bioscaffold design and lung tissue engineering
Establish, modify, and improve cell seeding methods to evaluate suitability of 3D printed bioscaffolds for cellularization efforts
Provide hands-on reduction to practice for manufacturing of prototypes for the Organ Manufacturing program
Perform cell studies to address technical and scientific challenges to support cellularization of 3D printed scaffolds
Independently and collaboratively develop and execute molecular and cellular assays to evaluate cell phenotype and function of cellularized 3D printed bioscaffolds
Independently and collaboratively develop and execute assessments to evaluate gas exchange and perfusibility of cellularized 3D printed bioscaffolds
Follow existing test practices and develop additional experimental plans to achieve project milestones; understanding and adhering to critical path activities and assembling equipment necessary to execute experimental plans for prototype development
Conduct (and supervise, if necessary) lab work and prototype performance testing; interpret data and results to provide guidance on design iterations
Make recommendations and set new directions for assigned projects based on data; testing results and feedback from 3D printing, scaffold design, and bioink development leads
Perform other duties as assigned
For this role you will need
PhD degree in Biomedical Engineering, Cell Biology, or related field
1-3 years of experience in an engineering R&D environment, not inclusive of time in graduate school
Demonstrated success (i.e. products and/or publications) and knowledge in tissue engineering and its related concepts; or cellularization of scaffolds design for tissue engineering applications
Knowledge of Aseptic Technique and mammalian cell culture
Knowledge of bioreactor development and assembly
Knowledge of Cell and biomaterials interaction
Knowledge of imaging and microscopy; and molecular biology assays and techniques
Proficient with MS Office (Excel, PowerPoint, Word)
Able to travel up to 10% as needed
Life as a Unitherian
At United Therapeutics, you’ll realize quickly that it is not an ordinary place to work! When you join our company, you will learn, grow, contribute, have fun, and be challenged... all while making a difference in the lives of our patients.
United Therapeutics Corporation is an Equal Opportunity/Affirmative Action Employer - EOE Minorities / Females / Protected Veterans / Individuals with Disabilities
We strive to be an organization that engages the minds, hearts, and most spirited efforts of each of our employees. Our sense of purpose transforms what we do from work into mission, occupation into vocation and achievement into success.
We challenge our employees with innovative and revolutionary projects, offer an environment which fosters high-level job performance and provide a highly competitive total rewards package. This is what makes United Therapeutics a stimulating place to work.
Internal Number: R01880
About Lung Biotechnology, PBC/United Therapeutics Corporation
United Therapeutics Corporation focuses on the strength of a balanced, value-creating biotechnology model. We are confident in our future thanks to our fundamental attributes, namely our obsession with quality and innovation, the power of our brands, our entrepreneurial culture and our bioinformatics leadership. We also believe that our determination to be responsible citizens — having a positive impact on patients, the environment and society — will sustain our success in the long term.
Through our wholly owned subsidiary, Lung Biotechnology PBC, we are focused on addressing the acute national shortage of transplantable lungs and other organs with a variety of technologies that either delay the need for such organs or expand the supply. Lung Biotechnology is the first public benefit corporation subsidiary of a public biotechnology or pharmaceutical company.
We currently have five approved products on the market and a long-term mission of providing an unlimited supply of transplantable organs for those who need them.
Our company was founded by an entrepreneur whose daughter was diagnosed with a life-threatening condition. She sought to find treatment options and a cure for h...er daughter and patients like her. We are founder-led, and relentless in our pursuit of “medicines for life”. We continue to research and develop treatments for cardiovascular and pulmonary diseases, pediatric cancers and other orphan diseases.